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  • 產品名稱:Z-LEVD-FMK

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  • 產品廠商:Biovision
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簡單介紹:
Z-LEVD-FMK
詳情介紹:
Purpose A caspase-4 inhibitor
Sequence Z-Leu-Glu(OMe)-Val-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits activity of LEVD-dependent caspases (e.g., caspase-4). The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity Single spot by TLC
Chemical Name Z-LEVD-FMK, Z-LEVD-fluoromethylketone, Caspase-4 Inhibitor (fluoromethylketone)
Formula C??H??FN?O??
Permeability Cell-permeable
Solubility DMSO (20 mM)
Molecular Weight 652.7 g/mol
Application Notes We recommend using 2-10 μM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Solid, Lyophilized
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Product cited in: Burm, Zuiderwijk-Sick, t Jong, van der Putten, Veth, Kondova, Bajramovic: "Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 2, pp. 678-87, 2015 (PubMed).

Binet, Chiasson, Girard: "Interaction between arsenic trioxide (ATO) and human neutrophils." in: Human & experimental toxicology, Vol. 30, Issue 5, pp. 416-24, 2011 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi, Slifker, Willis, Ramos, Tapia, Kim, Yerrum, Sharma, Nicolas, Balagurunathan, Ross, Jordan: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

Rosati, Sabatini, Rampino, De Falco, Di Ianni, Falzetti, Fettucciari, Bartoli, Screpanti, Marconi: "Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL." in: Blood, Vol. 116, Issue 15, pp. 2713-23, 2010 (PubMed).

Wei, Kadia, Tong, Zhang, Jia, Yang, Hu, Tambaro, Viallet, OBrien, Garcia-Manero: "The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 15, pp. 3923-32, 2010 (PubMed).

Akamatsu, Shibata, Ito, Sohma, Azuma, Otsuki: "Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress." in: Anticancer research, Vol. 29, Issue 6, pp. 2195-204, 2009 (PubMed).

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