|
Comment
|
A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC = 37 nM for hSCD1, <4 4="" nm="" for="" mscd1).="" also="" exhibited="" in="" vivo="" efficacy="" with="" dose-dependent="" desaturation="" index="" lowering="" effect.="" scd1="" inhibition="" resulted="" alterations="" macrophage="" membrane="" lipid="" composition="" and="" marked="" hypersensitivity="" to="" toll-like="" receptor="" agonists<="" p="">
|
