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Characteristics
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A potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO, IC50 = 300 nM). Does not affect catalase or glutathione peroxidase activities. Also displays no effect on the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60, human leukemia cells.
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