|
Purpose
|
A sub-nanomolar potent mTOR inhibitor
|
|
Characteristics
|
A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC?? = 0.45 nM nM). Displays 1469-fold selectivity over PI3Kα (IC?? = 661 nM).
|
|
Purity
|
≥ 98?% by HPLC
|
|
Chemical Name
|
4-{6-[4-(3-Cyclopropyl-ureido)-phenyl]-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid methyl ester
|
|
Formula
|
C??H??N?O?
|
|
Permeability
|
Cell-permeable
|
|
Solubility
|
DMSO (> 10 mg/mL)
|
