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產(chǎn)品詳情

  • 產(chǎn)品名稱：LY2811376

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：TargetMol
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
LY2811376
詳情介紹：
Purpose LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
Characteristics Target: BACE inhibitor,Beta amyloid inhibitor, Gamma-secretase
Receptor: BACE1, Beta Amyloid, Gamma-secretase
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 99.80?%
Formula C15H14F2N4S
Solubility 10 mM in DMSO and 200 mM in ethanol
Molecular Weight 320.36 g/mol
CAS-No 1194044-20-6
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months
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