99国产精品视频免费观看_国产一区毛片_久久激情视频免费观看_国产成人aa在线观看网站站

產(chǎn)品詳情

所在位置: 首頁(yè)> 產(chǎn)品目錄> 輔助試劑>

查看大圖

產(chǎn)品名稱：rlberiotoxin(IbTx)
產(chǎn)品型號(hào)：
產(chǎn)品廠商：BioLeaf
產(chǎn)品文檔：

你添加了1件商品查看購(gòu)物車

簡(jiǎn)單介紹：

rlberiotoxin(IbTx)

詳情介紹：

Product details
Product details
Sequence	QFTDVDCSVS KECWSVCKDL FGVDRGKCMG KKCRCYQ.
Specificity	Iberiotoxin is a potent selective blocker of the high conductance Ca2+-activated K+ channels (maxi-K).
Characteristics	Source: Mesobuthus tamulus (Eastern Indian scorpion). Molecular formula: C₁₇₉H₂₇₇N₅₁O₅₅S₇. Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.
Purity	> 98 %

Target details
Target details
Background	Inhibition of BKCa channels heterologously expressed in HEK293 cells by Iberiotoxin. mSlo channel currents, before and during application of 100nM rIberiotoxin. The mSlo currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10 M Ca2+.
Molecular Weight	4248

Application Details
Application Details
Application Notes	50-100 nM
Comment	K+ channel toxin -KTx 1.3
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Concentration after reconstitution: Dissolving 50 g in 1.175ml will provide a stock solution of 10 M.
Handling Advice	Soluble in Water.

Images
Images
Supplier Images	mSlo channel currents, before and during application of 100nM rIberiotoxin. The mSlo ... mSlo channel currents, before and during application of 100nM rIberiotoxin. The mSlo currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10 μM Ca2+. mSlo channel currents, before and during application of 100nM rIberiotoxin. The mSlo currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10 μM Ca2+.

References
References
Background publications	Meera, Wallner, Toro: "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 10, pp. 5562-7, 2000 (PubMed).
Product cited in:	Koschak, Koch, Liu, Kaczorowski, Reinhart, Garcia, Knaus: "[125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels." in: Biochemistry, Vol. 36, Issue 7, pp. 1943-52, 1997 (PubMed). Galvez, Gimenez-Gallego, Reuben, Roy-Contancin, Feigenbaum, Kaczorowski, Garcia: "Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus." in: The Journal of biological chemistry, Vol. 265, Issue 19, pp. 11083-90, 1990 (PubMed).

主站蜘蛛池模板：阿克苏市| 邢台市| 建始县| 奈曼旗| 鹤山市| 丰镇市| 永春县| 四川省| 汉阴县| 灵山县| 汉源县| 曲靖市| 罗山县| 阿鲁科尔沁旗| 凭祥市| 连州市| 平度市| 西吉县| 孟州市| 综艺| 凤阳县| 蓝田县| 香港 | 获嘉县| 东乌| 京山县| 通道| 科技| 义马市| 全椒县| 三台县| 同仁县| 庆安县| 五常市| 福建省| 牙克石市| 柯坪县| 永顺县| 新泰市| 吕梁市| 清水县|