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  • 產品名稱：rBeKm-1

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簡單介紹：
rBeKm-1
詳情介紹：
Sequence RPTDIKCSES YQCFPVCKSR FGKTNGRCVN GFCDCF.
Specificity BeKm-1 inhibits ERG1 K+ channel currents and has minimal effect on ELK1 K+ channels.
Characteristics Source: Buthus eupeus (Lesser Asian scorpion).
Molecular formula: C174H267N51O52S6.
Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.
Purity > 98 %
Background BeKm-1 inhibits Kv11.1 (hERG) channels expressed in HEK-293 cells. hERG channel currents, before and after application of 1nM rBeKm-1. hERG channel currents were elicited by stepping the potential to -50 mV to +50 mV in 10 mV steps (1-s test potentials) from a holding potential of -80 mV for activation.
Molecular Weight 4092
Application Notes 2-10 nM
Comment

K+ channel toxin -KTx 2.1
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.222ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Supplier Images
image for rBeKm-1 (ABIN1001693) hERG channel currents, before and after application of 1nM rBeKm-1. hERG channel curr...
Product cited in: Korolkova, Kozlov, Lipkin, Pluzhnikov, Hadley, Filippov, Brown, Angelo, Str?baek, Jespersen, Olesen, Jensen, Grishin: "An ERG channel inhibitor from the scorpion Buthus eupeus." in: The Journal of biological chemistry, Vol. 276, Issue 13, pp. 9868-76, 2001 (PubMed).

Filippov, Kozlov, Pluzhnikov, Grishin, Brown: "M-type K+ current inhibition by a toxin fron the scorpion Buthus eupeus." in: FEBS letters, Vol. 384, Issue 3, pp. 277-80, 1996 (PubMed).

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