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產(chǎn)品詳情

  • 產(chǎn)品名稱：rTertiapin(TPN)

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  • 產(chǎn)品廠商：BioLeaf
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簡單介紹：
rTertiapin(TPN)
詳情介紹：
Sequence ALCNCNRIII PHMCWKKCGK K.
Specificity Tertiapin blocks a range of inward rectifier K+ channels (Kir) in particular ROMK1 and GIRK but with no effect on Kir2 family members1. In addition, it was shown to inhibit acetylcholine induced K+ currents in heart2,3.
Characteristics Source: Apis mellifera (Honeybee).
Molecular formula: C106H175N33O23S5.
Disulfide bonds between Cys3-Cys14, and Cys5-Cys18.
Purity > 98 %
Molecular Weight 2456
Application Notes 10-100 nM
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 2.036 ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Drici, Diochot, Terrenoire, Romey, Lazdunski: "The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks." in: British journal of pharmacology, Vol. 131, Issue 3, pp. 569-77, 2000 (PubMed).

Kitamura, Yokoyama, Akita, Matsushita, Kurachi, Yamada: "Tertiapin potently and selectively blocks muscarinic K(+) channels in rabbit cardiac myocytes." in: The Journal of pharmacology and experimental therapeutics, Vol. 293, Issue 1, pp. 196-205, 2000 (PubMed).

Jin, Lu: "A novel high-affinity inhibitor for inward-rectifier K+ channels." in: Biochemistry, Vol. 37, Issue 38, pp. 13291-9, 1998 (PubMed).

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