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  • 產品名稱：rOsK-1

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簡單介紹：
rOsK-1
詳情介紹：
Sequence GVIINVKCKI SRQCLEPCKK AGMRFGKCMN GKCHCTPK.
Specificity OsK-1 inhibits Kv1.1, Kv1.2, Kv1.3 channels potently and KCa3.1channel moderately2.
Characteristics Source: Orthochirus scrobiculosus (Central Asian scorpion).
Molecular formula: C177H300N56O46S8.
Disulfide bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35.
Purity > 98 %
Molecular Weight 4205
Application Notes 5-100 nM
Comment

K+ channel toxin -KTx 3.7
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.190 ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Mouhat, Visan, Ananthakrishnan, Wulff, Andreotti, Grissmer, Darbon, De Waard, Sabatier: "K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom." in: The Biochemical journal, Vol. 385, Issue Pt 1, pp. 95-104, 2004 (PubMed).

Jaravine, Nolde, Reibarkh, Korolkova, Kozlov, Pluzhnikov, Grishin, Arseniev: "Three-dimensional structure of toxin OSK1 from Orthochirus scrobiculosus scorpion venom." in: Biochemistry, Vol. 36, Issue 6, pp. 1223-32, 1997 (PubMed).

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