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  • 產品名稱：rHg1

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簡單介紹：
rHg1
詳情介紹：
Sequence GHHNRVNCLL PPKTGPCKGS FARYYFDIET GSCKAFIYGG CEGNSNNFSE KHHCEKRCRG FRKFGGK.
Specificity Hg1 was a highly selective Kv1.3 channel inhibitor with weak affinity for other potassium channels. Hg1 also function as trypsin inhibitors with dissociation constants of 107 nM.
Characteristics Source: Hadrurus gertschi (Mexican scorpion)
Molecular formula: C329H490N102O92S6.
Disulfide bonds between Cys8-Cys58, Cys17-Cys41, and Cys33-Cys54.
Purity > 98 %
Molecular Weight 7538.5
Application Notes 6.2 +/- 1.2nM
Comment

Protease inhibitor Hg1
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 0.663 ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Chen, Hu, Yang, He, Feng, Wang, Zhao, Ding, Cao, Li, Wu: "Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family." in: The Journal of biological chemistry, Vol. 287, Issue 17, pp. 13813-21, 2012 (PubMed).

Schwartz, Diego-Garcia, Rodríguez de la Vega, Possani: "Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)." in: BMC genomics, Vol. 8, pp. 119, 2007 (PubMed).

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