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  • 產品名稱:Caspase-4InhibitorZ-LEVD-FMK

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  • 產品廠商:Biovision
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簡單介紹:
Caspase-4InhibitorZ-LEVD-FMK
詳情介紹:
Purpose A caspase-4 inhibitor
Sequence Z-Leu-Glu(OMe)-Val-Asp(OMe)-FMK
Characteristics PubChem CID: 44135220
A synthetic peptide that irreversibly inhibits activity of LEVD-dependent caspases (e.g., caspase-4). The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity > 95?% by HPLC
Chemical Name Z-LEVD-FMK, Caspase-4 Inhibitor (fluoromethylketone)
Formula C??H??FN?O??
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 652.7 g/mol
Application Notes We recommend using 1000-5000X dilutions for inhibiting caspase-4 and related caspase activity (e.g., Add 1 μL to 1-5 mL of culture medium). However, the optimal doses may vary for different cells and culture conditions. The inhibitor is designed as a methyl ester to facilitate cell permeability.
Restrictions For Research Use only
Format Liquid
Concentration 10 mM
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Product cited in: Akamatsu, Shibata, Ito, Sohma, Azuma, Otsuki: "Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress." in: Anticancer research, Vol. 29, Issue 6, pp. 2195-204, 2009 (PubMed).

Chen, Jiang, Watts, Thorne, Kiejda, Zhang, Hersey: "Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein." in: Cancer research, Vol. 68, Issue 3, pp. 834-42, 2008 (PubMed).

Jiang, Chen, Gillespie, Wang, Kiejda, Zhang, Hersey: "Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis." in: Cancer research, Vol. 67, Issue 20, pp. 9750-61, 2007 (PubMed).

Kim, Zhang, Hitomi, Lee, Mukherjee: "Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL." in: Human molecular genetics, Vol. 15, Issue 11, pp. 1826-34, 2006 (PubMed).

Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

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