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Characteristics
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A potent inhibitor of the beta-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an IC50 of 18 nM. It acts by disrupting the interaction between beta-catenin and TCF4, possibly by direct binding to beta-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.
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