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Characteristics
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AT-56 is a selective, competitive, and highly bioavailable inhibitor of L-PGDS (lipocalin-type prostaglandin D synthase) (Ki = 75 μM). It inhibits the production of PGD2 by L-PGDS purified from human CSF and recombinant mouse cells with an IC?? value of 95 μM. At concentrations as high as 100 μM in vitro or 30 mg/kg in vivo, AT-56 does not affect the production of PGE2, PGF2α, or H-PGDS-catalyzed PGD2. PubChem CID: 11741525
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