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Purpose
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LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
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Characteristics
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Target: BACE inhibitor,Beta amyloid inhibitor, Gamma-secretase
Receptor: BACE1, Beta Amyloid, Gamma-secretase
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Purification
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All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
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Purity
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99.80?%
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Formula
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C15H14F2N4S
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Solubility
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10 mM in DMSO and 200 mM in ethanol
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