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Background
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MeOSuc-Ala-Phep(Oph)2 is a Peptidyl Amino- alkanephosphonate Inhibitor (DAP). The DAP inhibitors, which can be used as an alternative to the Chloromethyl Ketone derivatives (CMK), are serine specific and non-thio reactive. Features of Peptidyl Amino-alkanephosphonate (DAP):
non-alkalating
stable in aqueous solution
minimal toxicity
serine specific
cell permeable.
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