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產(chǎn)品詳情

  • 產(chǎn)品名稱：Fostriecin

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：KamiyaBiomedical
  • 產(chǎn)品文檔：
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簡單介紹：
Fostriecin
詳情介紹：
Sequence 2H-Pyran-2-one, 5,6-dihydro-6-[3,6, 13- trihydroxy -3methyl-4-(phosphonoo xy)-1, 7, 9, 11-tridecatet raenyl]-monosodium salt
Characteristics Strong inhibitor of serine/threonine protein phosphatase type 2A (IC50 3.2 nM) and weak inhibitor of protein phosphatase type 1 (IC50 131 μM). Fostriecin has no apparent effect on PP2B. The on PP2A is different than that for okadaic acid. An earlier report shows slightly less selectivity for PP2A. Fostriecin has also been reported to inhibit topoisomerase II. Reported consequences of treating cells with fostriecin include override of the mitotic checkpoint, G2-M phase growth arrest associated with abnormal centrosome replication and formation of aberrant mitotic spindles, vimentin hyperphosphorylation and intermediate filament reorganization.
Purity > 98 % (HPLC)
Molecular Weight 452.4 Da
Comment

Formula: C19H26O9PNa
Restrictions For Research Use only
Format Solid
Reconstitution Soluble in water, methanol and ethanol. Fostriecin is freely soluble in water. However, stability is reduced in the absence of sodium, and at pH values greater than neutral. It is recommended that fostriecin be dissolved in a sodium phosphate buffer with a pH not exceeding 7.5.
Buffer Packaged under argon gas in borsilicate glass vial with teflon-lined crimp closure.
Storage 4 °C
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