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產品名稱：rBmKTX
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產品廠商：BioLeaf
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rBmKTX

詳情介紹：

Product details
Product details
Sequence	VGINVKCKHS GQCLKPCKDA GMRFGKCING KCDCTPK.
Specificity	Voltage-gated channel (Kv1.3) blocker. rBmKTX blocks Kv1.3 channels with IC50 of 019 nM.
Characteristics	Source: Mesobuthus Martensii (Buthus martensii). Molecular formula: C₁₆₉H₂₇₄N₅₂O₄₇S₇. Disulfide bonds between Cys7-Cys27, Cys13-Cys32, and Cys17-Cys34.
Purity	> 98 %

Target details
Target details
Background	BmKTX inhibits Kv1.3 channels heterologously expressed in HEK-293 cells. Kv1.3 channel currents, before and after application of 100pM BmKTX. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV.
Molecular Weight	3962

Application Details
Application Details
Application Notes	0.1-1nM
Comment	K+ channel toxin -KTx 3.6
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Concentration after reconstitution: Dissolving 50g in 1.262ml will provide a stock solution of 10 M.
Handling Advice	Soluble in Water.

Images
Images
Supplier Images	Kv1.3 channel currents, before and after application of 100pM BmKTX. Kv1.3 channel cu... Kv1.3 channel currents, before and after application of 100pM BmKTX. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV. Kv1.3 channel currents, before and after application of 100pM BmKTX. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV.

References
References
Product cited in:	Renisio, Romi-Lebrun, Blanc, Bornet, Nakajima, Darbon: "Solution structure of BmKTX, a K+ blocker toxin from the Chinese scorpion Buthus Martensi." in: Proteins, Vol. 38, Issue 1, pp. 70-8, 2000 (PubMed). Dai, Wu, Gu, Lan, Ling, Chi: "Genomic organization of three novel toxins from the scorpion Buthus martensi Karsch that are active on potassium channels." in: The Biochemical journal, Vol. 346 Pt 3, pp. 805-9, 2000 (PubMed). Romi-Lebrun, Lebrun, Martin-Eauclaire, Ishiguro, Escoubas, Wu, Hisada, Pongs, Nakajima: "Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels." in: Biochemistry, Vol. 36, Issue 44, pp. 13473-82, 1997 (PubMed).

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