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產品名稱：rBeKm-1
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產品廠商：BioLeaf
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rBeKm-1

詳情介紹：

Product details
Product details
Sequence	RPTDIKCSES YQCFPVCKSR FGKTNGRCVN GFCDCF.
Specificity	BeKm-1 inhibits ERG1 K+ channel currents and has minimal effect on ELK1 K+ channels.
Characteristics	Source: Buthus eupeus (Lesser Asian scorpion). Molecular formula: C₁₇₄H₂₆₇N₅₁O₅₂S₆. Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.
Purity	> 98 %

Target details
Target details
Background	BeKm-1 inhibits Kv11.1 (hERG) channels expressed in HEK-293 cells. hERG channel currents, before and after application of 1nM rBeKm-1. hERG channel currents were elicited by stepping the potential to -50 mV to +50 mV in 10 mV steps (1-s test potentials) from a holding potential of -80 mV for activation.
Molecular Weight	4092

Application Details
Application Details
Application Notes	2-10 nM
Comment	K+ channel toxin -KTx 2.1
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Concentration after reconstitution: Dissolving 50g in 1.222ml will provide a stock solution of 10 M.
Handling Advice	Soluble in Water.

Images
Images
Supplier Images	hERG channel currents, before and after application of 1nM rBeKm-1. hERG channel curr... hERG channel currents, before and after application of 1nM rBeKm-1. hERG channel currents were elicited by stepping the potential to ?50 mV to +50 mV in 10 mV steps (1-s test potentials) from a holding potential of ?80 mV for activation. hERG channel currents, before and after application of 1nM rBeKm-1. hERG channel currents were elicited by stepping the potential to ?50 mV to +50 mV in 10 mV steps (1-s test potentials) from a holding potential of ?80 mV for activation.

References
References
Product cited in:	Korolkova, Kozlov, Lipkin, Pluzhnikov, Hadley, Filippov, Brown, Angelo, Str?baek, Jespersen, Olesen, Jensen, Grishin: "An ERG channel inhibitor from the scorpion Buthus eupeus." in: The Journal of biological chemistry, Vol. 276, Issue 13, pp. 9868-76, 2001 (PubMed). Filippov, Kozlov, Pluzhnikov, Grishin, Brown: "M-type K+ current inhibition by a toxin fron the scorpion Buthus eupeus." in: FEBS letters, Vol. 384, Issue 3, pp. 277-80, 1996 (PubMed).

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