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產品名稱：ADWX-1
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產品廠商：BioLeaf
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ADWX-1

詳情介紹：

Product details
Product details
Sequence	VGINVKCKHS RQCLKPCKDA GMRFGKCTNG KCHCTPK.
Specificity	Voltage-gated channel (Kv1.3 and Kv1.1) blocker. ADWX-1 blocks Kv1.3 channels with IC50 of 019 nM, and inhibits Kv1.1 channels with IC50 of 0.65nM.
Characteristics	Source: Mesobuthus Martensii (Buthus martensii). Molecular formula: C₁₆₉H₂₈₁N₅₇O₄₆S₇. Disulfide bonds between Cys7-Cys27, Cys13-Cys32, and Cys17-Cys34.
Purity	> 98 %

Target details
Target details
Background	ADWX-1 inhibits Kv1.3 channels heterologously expressed in HEK-293 cells. Kv1.3 channel currentsbefore and after application of 10pM ADWX-1. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV.
Molecular Weight	4072

Application Details
Application Details
Application Notes	019-0.65nM
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Concentration after reconstitution: Dissolving 50g in 1.228ml will provide a stock solution of 10M.
Handling Advice	Soluble in Water.

Images
Images
Supplier Images	Kv1.3 channel currents, before and after application of 10pM ADWX-1. Kv1.3 channel cu... Kv1.3 channel currents, before and after application of 10pM ADWX-1. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV. Kv1.3 channel currents, before and after application of 10pM ADWX-1. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV.

References
References
Product cited in:	Yin, Jiang, Yi, Han, Yang, Liu, Liu, Cao, Wu, Li: "Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels." in: Journal of proteome research, Vol. 7, Issue 11, pp. 4890-7, 2008 (PubMed). Han, Yi, Yin, Chen, Liu, Cao, Wu, Li: "Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease." in: The Journal of biological chemistry, Vol. 283, Issue 27, pp. 19058-65, 2008 (PubMed).

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