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產(chǎn)品名稱：rMargatoxin(MgTX)
產(chǎn)品型號(hào)：
產(chǎn)品廠商：BioLeaf
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rMargatoxin(MgTX)

詳情介紹：

Product details
Product details
Sequence	TIINVKCTSP KQCLPPCKAQ FGQSAGAKCM NGKCKCYPH.
Specificity	Margatoxin is a potent selective inhibitor of voltage-dependent potassium channels such as Kv1.3.
Characteristics	Source: Centruroides margaritatus (Scorpion). Molecular formula: C₁₇₈H₂₈₆N₅₂O₅₀S₇. Disulfide bonds between Cys7-Cys29, Cys13-Cys34, and Cys17-Cys36.
Purity	> 98 %

Target details
Target details
Molecular Weight	4179

Application Details
Application Details
Application Notes	50pM - 50nM
Comment	K+ channel toxin -KTx 2.2
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Concentration after reconstitution: Dissolving 50g in 1.196 ml will provide a stock solution of 10 M.
Handling Advice	Soluble in Water.

Images
Images
Supplier Images	SKCa3 channel currents, before and after application of 100nM Tamapin. The SKCa curre... SKCa3 channel currents, before and after application of 100nM Tamapin. The SKCa currents were elicited by 1μM internal calcium and 200 ms voltage ramps from -140 to +40 mV at the holding potential of 0 mV. SKCa3 channel currents, before and after application of 100nM Tamapin. The SKCa currents were elicited by 1μM internal calcium and 200 ms voltage ramps from -140 to +40 mV at the holding potential of 0 mV.

References
References
Product cited in:	Garcia-Calvo, Leonard, Novick, Stevens, Schmalhofer, Kaczorowski, Garcia: "Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels." in: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18866-74, 1993 (PubMed). Leonard, Garcia, Slaughter, Reuben: "Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 21, pp. 10094-8, 1992 (PubMed).

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