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  • 產品名稱：Tamapin

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簡單介紹：
Tamapin
詳情介紹：
Sequence AFCNLRRCEL SCRSLGLLGK CIGEECKCVP Y.
Specificity Tamapin blocks KCa2 channels, a highly potent blocker towards KCa2 channels.
Characteristics Source: Mesobuthus tamulus (Eastern Indian scorpion).
Molecular formula: C146H240N44O41S6.
Disulfide bonds between Cys3-Cys21, Cys8-Cys26, and Cys12-Cys28.
Purity > 98 %
Background Tamapin inhibits SKCa3 channels heterologously expressed in HEK-293 cells. SKCa3 channel currents, before and after application of 100nM Tamapin. The SKCa currents were elicited by 1μM internal calcium and 200 ms voltage ramps from -140 to +40 mV at the holding potential of 0 mV.
Molecular Weight 3459
Application Notes 10-100nM
Comment

K+ channel toxin -KTx 5.4
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.446 ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Rodríguez de la Vega, Possani: "Current views on scorpion toxins specific for K+-channels." in: Toxicon : official journal of the International Society on Toxinology, Vol. 43, Issue 8, pp. 865-75, 2004 (PubMed).

Pedarzani, Dhoedt, Doorty, Wadsworth, Joseph, Jeyaseelan, Kini, Gadre, Sapatnekar, Stocker, Strong: "Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons." in: The Journal of biological chemistry, Vol. 277, Issue 48, pp. 46101-9, 2002 (PubMed).

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