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產品名稱：rTertiapin(TPN)
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產品廠商：BioLeaf
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rTertiapin(TPN)

詳情介紹：

Product details
Product details
Sequence	ALCNCNRIII PHMCWKKCGK K.
Specificity	Tertiapin blocks a range of inward rectifier K+ channels (Kir) in particular ROMK1 and GIRK but with no effect on Kir2 family members1. In addition, it was shown to inhibit acetylcholine induced K+ currents in heart2,3.
Characteristics	Source: Apis mellifera (Honeybee). Molecular formula: C₁₀₆H₁₇₅N₃₃O₂₃S₅. Disulfide bonds between Cys3-Cys14, and Cys5-Cys18.
Purity	> 98 %

Target details
Target details
Molecular Weight	2456

Application Details
Application Details
Application Notes	10-100 nM
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Concentration after reconstitution: Dissolving 50g in 2.036 ml will provide a stock solution of 10 M.
Handling Advice	Soluble in Water.

References
References
Product cited in:	Drici, Diochot, Terrenoire, Romey, Lazdunski: "The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks." in: British journal of pharmacology, Vol. 131, Issue 3, pp. 569-77, 2000 (PubMed). Kitamura, Yokoyama, Akita, Matsushita, Kurachi, Yamada: "Tertiapin potently and selectively blocks muscarinic K(+) channels in rabbit cardiac myocytes." in: The Journal of pharmacology and experimental therapeutics, Vol. 293, Issue 1, pp. 196-205, 2000 (PubMed). Jin, Lu: "A novel high-affinity inhibitor for inward-rectifier K+ channels." in: Biochemistry, Vol. 37, Issue 38, pp. 13291-9, 1998 (PubMed).

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