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  • 產品名稱：s-Pompilidotoxin(PMTX)

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  • 產品廠商：BioLeaf
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簡單介紹：
s-Pompilidotoxin(PMTX)
詳情介紹：
Sequence RIKIGLFDQL SRL.
Specificity -Pompilidotoxin slows Nav channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse1-3. -Pompilidotoxin is five times more potent than -Pompili
Characteristics Source: Batozonellus maculifrons (Solitary wasp).
Molecular formula: C71H124N22O17.
Lys13 - C-terminal amidation.
Purity > 98 %
Molecular Weight 1559
Application Notes 10-100 M
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 3.207ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Sahara, Gotoh, Konno, Miwa, Tsubokawa, Robinson, Kawai: "A new class of neurotoxin from wasp venom slows inactivation of sodium current." in: The European journal of neuroscience, Vol. 12, Issue 6, pp. 1961-70, 2000 (PubMed).

Konno, Hisada, Naoki, Itagaki, Yasuhara, Nakata, Miwa, Kawai: "Molecular determinants of binding of a wasp toxin (PMTXs) and its analogs in the Na+ channels proteins." in: Neuroscience letters, Vol. 285, Issue 1, pp. 29-32, 2000 (PubMed).

Konno, Hisada, Itagaki, Naoki, Kawai, Miwa, Yasuhara, Takayama: "Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms." in: Biochemical and biophysical research communications, Vol. 250, Issue 3, pp. 612-6, 1998 (PubMed).

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