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Background
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RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation.
Alias Symbols: CCYC, FLJ41520, HRAD17, R24L, RAD17SP, RAD24
Protein Interaction Partner: ATM,ATR,HUS1,MCM7,NHP2L1,POLE,RAD1,RAD9A,RAD9B,RFC4,ALK,ATM,ATR,CLSPN,FOXO3,H2AFX,HUS1,NHP2L1,POLE,POLE2,POLE3,POLE4,PRKDC,RAD1,RAD9A,RAD9B,RFC1,RFC2,RFC3,RFC4,RFC5,USP20
Protein Size: 670
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